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The peptide clears from plasma within 4 to 6 hours after injection

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Concentration (start) Volume (start) = Concentration (final) Volume (final) Purity & Documentation Data Sheet (270 KB) SDS (252 KB) English - EN (252 KB) Franais - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Espaol - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB) Handling Instructions (2659 KB) References [1]

dose-dependent GI adverse events (nausea, vomiting) similar to other amylin analogues Exposure: Dose-proportional increases in Cmax and AUC Gastric Effects: Dose-dependent slowing of gastric emptying confirmed via paracetamol absorption test Appetite Suppression: Reduced ad libitum food intake at doses 1.2 mg Clinical Significance: Established feasibility of once-weekly dosing and identified dose range for Phase 2 studies

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