alpha-synuclein oligomers induce glutamate release from astrocytes and excessive extrasynaptic NMDAR activity in neurons, thus contributing to synapse loss
Significance was determined by one-way repeated measures analysis of variance, and the HolmSidak method for multiple comparisons versus the control group, using SigmaPlot 10.0 software (Systat Software, San Jose, CA, USA)
Furin is a member of the proprotein convertase subtilisin/kexin (PCSK) type family of proteases and as such is also identified as PCSK3
Microglial activation has been found with a greater density in the SNpc (Lawson et al., 1990) and in the olfactory bulb of both sporadic and familial PD patients (McGeer et al., 1988
Kyn stimulated mTOR in DN T cells (Fig
Structure-function relations, physiological roles, and evolution of mammalian ER-resident selenoproteins