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Conversely, others and our laboratory have demonstrated that NO can favor GSH synthesis via the NEFL2-mediated transcription of GCL ( The role of GSH as NO scavenger is also highlighted by To investigate the importance of correct GSH homeostasis for the neurotrophic capacity of NO, 2 -Tyr) protein accumulation ( Figure 1 )

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FIGURE 7 Discussion The contribution of oxidative metabolism of AQ to cytotoxicity has previously been demonstrated by several studies (Naisbitt et al., 1998

Upon oxidation, bilirubin is converted into various forms of bilirubin oxidation metabolites (BOMs), comprising at least seven hydrophilic metabolites that are promptly excreted into urine because of their hydrophilic nature (132)

doi: 10.1016/j.cmet.2019.06.016 31 WenZJinKShenYYangZLiYWuBet al