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Results RaPID selection of anti-Met macrocycles and in vitro characterizations The RaPID system consists of the following techniques: (1) the flexizyme integrated translation (FIT) system 14 that facilitates genetic code reprogramming of non-proteinogenic amino acids and (2) messenger RNA display 15,16 that fuses the expressed peptide (phenotype) with its cognate mRNA (genotype), enabling amplification of activity-enriched phenotypes (Supplementary Fig

doi: 10.1016/0024-3205(88)90427-4 100 MagiakouMAMastorakosGGomezMTRoseSRChrousosGP

17 , and Mohyeldin et al

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