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Matrix metalloproteinases (MMPs), regulated by their endogenous inhibitorstissue inhibitors of metalloproteinases (TIMPs) (Ruth, Day et al.) (Ruth, Day et al.)are critical for ECM breakdown and the promotion of angiogenesis (Zafrakas et al., 2020)
When the concentration of the lipid peroxidation product 4-HNE is relatively low, it can augment IKB kinase (IKK) activity, promoting IKB phosphorylation
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doi: 10.1155/2013/695936
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