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[18] Large amounts can induce tremors, vertigo, muscle twitches, paranoia, or, with repeated doses, a toxic reaction closely resembling amphetamine poisoning

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The amount of nicotine determined by a smoking machine using the ISO method, compared with the amount of nicotine that a smoker actually inhales (based on Jarvis et al

John Buck, 41, Lancashire: I had dreamed of running a pub but the ban ruined the industry Smoker I worked for a small brewery at the time and was personally against the ban, as were many landlords and staff

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Feeling unwell