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Granzyme A (GzmA) cleaves GSDMB (Zhou et al., 2020), and caspase-1 cleaves GSDMA (Billman et al., 2024)

This is a mission-critical step

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Peptides are known as structurally precise compounds

Deficiencies of other enzymes are rarer and have highly variable clinical phenotypes that may be specific for each enzymatic defect