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Biomarkers for alzheimers disease Given the failure of amyloid plaque clearance drugs, and the likelihood that the current focus on tau aggregation inhibitors will also yield disappointing results, new therapeutic approaches are clearly needed to alter clinical outcome for Alzheimers patients

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Combined Approaches (Neelakantan et al., 2022): NNMT inhibition with reduced-calorie diet produced dramatic adiposity reduction in DIO mice, normalizing metabolic parameters and establishing a distinct gut microbiome