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J Exp Biol 1998, 201: 11411152

dermal melanophages in mixed types and density of melanin in basal layer in both epidermal and mixed types of melasma (Fig

Bertini et al

In general, M1 macrophages have a phenotype of ferritin high , TfR high and FPN low , so they tend to retain iron and remove it from the exterior, which has been shown to enhance their antimicrobial effector functions such as ROS production

140 Thus, cysteine contributes to the inhibition of ferroptosis both as a component of glutathione, which facilitates the scavenging of lipid peroxides by the phospholipid hydroperoxidase glutathione peroxidase 4 (GPX4), and as a substrate of NFS1

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