This does not completely negate the peptide, but it reduces efficiency
A vitamin B12 injection is needed after gastric banding when oral supplementation has failed to correct a documented deficiency, serum B12 remains persistently low, the patient cannot adhere to daily oral tablets, or there are signs of neurological or haematological complications
11 CDC (Subcut Injection PDF)Technique diagram and site guidance for subcutaneous injections
Studies have shown that the peptide demonstrates approximately 40% oral bioavailability in animal models and exhibits rapid metabolism with a serum half-life of approximately 4 minutes, though its metabolic effects persist significantly longer due to downstream cellular activation
Unlike oral B12, which depends on intrinsic factor and healthy gut absorption, the injection delivers B12 directly into the bloodstream
Skipping the off-period leads to diminishing returns as receptor sensitivity declines