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Sleep Med Rev 10(1):4962

Concretely, the first signal of cell activation is specifically obtained by naive CD4 + T cells through the interaction of their T cell receptor (TCR) with the antigenic peptide MHC class II (MHC-II) molecular complex that is displayed on the surface of antigen presenting cells (APCs) ( + T cells combine with the corresponding ligand (such as B7) on the surface of APCs and the costimulatory molecule (such as CD28) expressed on its surface ( + T cells become activated, immediately after which they need to take up large amounts of Gln and glucose to meet the biosynthesis materials and energy required for proliferation/differentiation ( + T cells subsequently differentiate into various subtypes under the influence of various cytokines in the microenvironment

Improving protein-ligand docking results with high-throughput molecular dynamics simulations